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Excellent 4.7
Trusted by +1300 clients

Holist Synaptic

Ultra-Mushroom Complex

Stop feeling mentally drained.

Long days and constant context-switching chip away at attention. You push with caffeine, crash by noon, and your mind never fully resets.

Let’s get you back to:

  • Calm, clean energy
  • Steady, clear focus
  • Balanced vitality
  • Natural mental clarity
  • Made with Love
  • 30-Day Return
  • Ships Overnight in the U.S.
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Money-Back GuaranteeClinically Studied MushroomsImmune System Support*Cognitive Function Boost*Helps Defeat Aging*Anti-Inflammatory Power*
Money-Back GuaranteeClinically Studied MushroomsImmune System Support*Cognitive Function Boost*Helps Defeat Aging*Anti-Inflammatory Power*

What Our Customers Have To Say

Say stop to mental fatigue and drained focus — from home.

Long days, endless tabs, and too many thoughts at once — it’s no wonder your mind feels foggy. Modern life runs on overdrive, leaving the brain overstimulated and the body running on fumes.

You push through with caffeine, then crash. You forget what you just read. Even rest doesn’t feel refreshing — like your mind never really resets.

It doesn’t have to stay that way. Nature has long held the key to restoring clarity and balance — not by forcing energy, but by nurturing it.

Synaptic blends four powerful functional mushrooms — Lion’s Mane, Reishi, Cordyceps, and Shiitake — trusted for centuries to help sharpen focus, fortify immunity, and stabilize energy. Thoughtfully crafted for steady clarity and calm strength — so you feel centered, clear, and fully present.*

Backed by research, rooted in traditionsupports clarity, focus, immune defense, and calm vitality crafted for daily use to help you feel balanced, centered, and alert*

Find relief from that tired-all-the-time feeling — naturally.

Waking up tired, reaching for another cup of coffee, and watching your energy fade before the day’s halfway through? It’s not just lack of sleep — it’s your body asking for restoration, not stimulation.

When stress stacks and energy reserves run low, it’s easy to feel run-down or catch every cold. Over time, that constant strain dulls focus and leaves the body in a loop of exhaustion.

Synaptic helps the body rebuild its natural rhythm. Instead of masking tiredness, it nourishes the systems behind energy and focus — supporting calm endurance, mental clarity, and everyday resilience.*

Two of its core mushrooms target the most common challenges directly: Lion’s Mane is known for supporting concentration and cognitive sharpness, helping you stay focused when your mind starts to drift.* Cordyceps works on the other side — promoting cellular energy and endurance, so you feel less drained and more capable throughout the day.*

Steady energy, balanced mindsupports vitality, clarity, and calm endurance best felt with consistent, mindful use*
  • Lion’s Mane

    Promotes mental clarity, memory and focus.*

  • Cordyceps

    Boosts energy, stamina, and resilience under stress.*

  • Reishi

    Supports immunity and promotes calm focus.*

  • Shiitake

    Supports immune strength, heart health, and cellular protection.*

See And Feel The Difference Synaptic Makes

No snake oil. No bunk science. Synaptic is rigorously tested and designed for real results.

Georgeta E.

 Verified Customer

I didn't expect to see results so quickly...

Anti-Aging SupportImmunity SupportBrain Enhancement Support
  • 1 – 3 months - Sharper focus & calm energy

    You may notice quicker recall, fewer afternoon slumps, and a subtle lift in mood.

  • 4 – 6 months - Gut harmony & immune strength

    Adaptogens reach full saturation. β-glucans train immune cells for faster, smarter responses. Hair and nails often feel stronger thanks to extra antioxidants and amino acids.

  • 6+ months - Visible vitality & healthy aging

    Long-term energy production improves as mitochondrial efficiency is optimized. You’ll feel (and friends will see) a balanced, vibrant you—inside and out.

Backed by clinical research on mushrooms — designed for daily balance.

Clinical studies on Lion’s Mane, Reishi, Cordyceps, and Shiitake have shown measurable benefits in focus, energy metabolism, and stress response. Synaptic brings these time-tested ingredients together to help restore balance between mind, body, and energy.

Two of the most restorative mushrooms in the blend — Reishi and Shiitake — support your natural defenses and inner calm. Reishi promotes deeper rest and a more balanced stress response, while Shiitake strengthens immunity through natural beta-glucans, helping your body stay resilient through everyday challenges.

How to use: Take 2 capsules with water, ideally in the morning. For best absorption, pair with a light breakfast or tea. Most users begin noticing clearer focus and steadier energy within 5–10 days of consistent use.

Make it a ritual. Treat Synaptic as part of your morning flow — after hydration, before work, or during quiet reflection. It’s a small act of consistency that helps strengthen clarity, calm, and daily resilience.

Inspired by research, built for balancesupports focus, energy, and stress resilience
daily use helps maintain clarity and calm from the inside out
Synaptic Other Brands
Clinically Studied Mushrooms Science-backed mushrooms only
No Junk Inside Clean, effective, essential
Feel Long-Term Long-lasting effects
Designed to Impress Luxury meets function
Truly Holistic Health Rooted in real research

Don't Fall For Knockoffs

In between the fakes, our original device remains the best choice.

Immunity That Lasts

Natural daily defense

FREE & FAST SHIPPING

Worldwide delivery

RETURNS ACCEPTED

Easy return process

SECURE PAYMENT

Protected transactions

Why Synaptic Wins — for you.

You’ve tried it all — endless coffees, expensive vitamins, quick-fix programs that promise clarity but only leave you chasing another boost. Synaptic was made to help you feel steady, focused, and calm — without the rollercoaster or the recurring costs.*

At the price of a few lattes a week, you’re replacing countless small expenses: energy drinks, stress supplements, focus hacks — all temporary fixes that never build real balance. One daily ritual that actually works saves both your energy and your wallet.*

Synaptic supports you where you live — in the moments between deadlines, commutes, and late nights. It helps restore what modern life drains: clarity, stamina, patience, and a sense of control. The result isn’t a “boost” — it’s getting yourself back.*

No weekly therapy sessions, no daily caffeine crash, no overpriced adaptogen powders collecting dust. Just clean, proven ingredients that your body already understands — working quietly, every day, to help you stay balanced.*

Smart wellness investmentmore results, less waste replaces endless small fixes with one steady ritual that pays you back daily*
  • Made in the USA

    Produced locally for full transparency, consistent quality, and faster delivery to your door.

  • NSF Certified

    Backed by trusted third-party testing, so you get exactly what’s on the label — nothing more, nothing less.

  • GMP Certified

    Every batch is made under strict standards to ensure it’s clean, safe, and exactly what your body needs.

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Frequently Asked Questions

What is Holist™?

Holist™ is a Made in USA premium supplement brand dedicated to enhancing overall health and wellness. Our products, including our flagship Synaptic mushroom-based supplement, are crafted with the highest quality ingredients to support your body, mind, and spirit.

How long does it take to see results?

Some users experience results like improved brain function and clear skin within hours. For more visible benefits — like long-term memory, stronger hair, and revitalized skin — consistent daily use over 3 to 6 months is key.*

What makes Holist™ supplements different from other brands?

Holist supplements are rigorously tested and adhere to the highest quality standards. Our products are produced in FDA-registered facilities and undergo stringent testing to ensure unmatched purity, safety, and efficacy. We use only the finest ingredients, backed by scientific research. We do not compromise.

Are Holist™ supplements safe?

Yes, Holist™ supplements are safe when used as directed. We prioritize your health by using high-quality, natural ingredients and ensuring our products meet rigorous safety and quality standards. However, we always recommend consulting with a healthcare provider before starting any new supplement regimen.

Are Holist™ supplements suitable for vegetarians or vegans?

Yes, Holist™ Synaptic is suitable for vegetarians. We use plant-based ingredients and ensure that our products are free from animal-derived ingredients. Always check the product label for specific dietary information.